Stroke therapy put to the test in preclinical randomized controlled trial

In the midst of what some call a "crisis" in the ability to replicate results of laboratory studies, a European consortium has conducted a preclinical randomized controlled trial (pRCT), which mimics the design and rigorous standards of a clinical trial but is done in animals, and provides one more view of the drug's efficacy before it is used in the clinical trial setting.

The study evaluated a potential stroke therapy that had proved effective in one mouse model but not another, yet is already in phase 2 clinical trials.…

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