Blood clotting protein triggers immune attack on the brain

Disruption of the blood-brain barrier triggers a cascade of events that results in autoimmunity and brain damage characteristic of multiple sclerosis

A new study from the Gladstone Institutes shows that a single drop of blood in the brain is sufficient to activate an autoimmune response akin to multiple sclerosis (MS). This is the first demonstration that introduction of blood in the healthy brain is sufficient to cause peripheral immune cells to enter the brain, which then go on to cause brain damage.

A break in the blood-brain barrier…

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