Antioxidant Lipoic Acid Reduces Brain Tissue Loss in Small Trial Involving People with Secondary-Pro


  • In a study of 51 people with secondary progressive MS, the antioxidant lipoic acid was shown to reduce the rate of brain tissue loss compared to placebo. Walking improved, but not significantly.
  • Safety issues included stomach upset and two cases of kidney dysfunction.
  • The researchers are planning a larger, phase 2 clinical trial to further evaluate whether lipoic acid is a safe and effective treatment for progressive MS.
  • The team (Rebecca Spain, MD, MSPH, Oregon Health & Science University, and colleagues) report their findings in Neurology & Neuroinflammation,…

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